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runx bet agent list RUNX proteins contain a well-conserved DNA-binding domain (Runt domain). Heterodimerization with an essential binding partner protein, core binding factor beta (CBFβ), increases the DNA binding affinity of RUNX proteins (Wang et al., 1996b).Transcripts generated from the Cbfb gene is also subjected to alternative splicing .

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Runx-binding sites are frequently found within accessible chromatin regions of both memory CD4 and CD8 T cells (together with ETS family, Sp1 and T-bet motifs) (155, 162). Upon activation, inducible TFs, such as AP-1, NFAT1 and NF-κB, bind to silent chromatin in naïve T cells and initiate cytokine signaling.

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